Medium optimization fot the production of Actinomycin-D by Streptomyces parvulus

The present work aims to optimize the complex medium for the production of actinomycin-D by S.parvulus. The quantitative influence of the medium components was investigated in order to maximize the antibiotic synthesis. In the original medium, concentrations of actinomycin-D not higher than 245 ug/ml were achieved. In contrast, with the optimized medium the antibiotic concentration reached a value of approximately 530 ug/ml